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Istisu settlement is a residential area located in the Kalbajar district of Azerbaijan. The settlement is known for its mineral springs, and there are therapeutic water sources found here. During the Soviet period, Istisu was famous for its sanatorium, and many tourists used to visit the area. Since 2020, reconstruction and restoration work have been carried out in the region once again. Istisu's mineral waters are believed to have beneficial properties for health. The main activities in the settlement are tourism and sanatorium services.